From 2001 to 2009, Egusquiza served as Manager and was promoted to Director of Community Development and International Strategy for Ford Motor Company Fund, where she managed corporate relations and philanthropic initiatives for over 200 organizations and programs. In 1999-2001, she was employed by AT&T as Vice President, Legislative Affairs, were she tracked key telecommunications business related legislation and served as a registered lobbyist with local, state legislative and executive branches of government. She also served as Director of Government Relations for South Florida during her tenure with AT&T. Additionally, Egusquiza worked with Miami-Dade County Government as Executive Director of the Dade County Legislative Delegation and Community Outreach Specialist and with the Florida Senate as a Legislative Assistant.
Egusquiza has served on the board of numerous nonprofits and currently serves as a member of the Corporate Advisory Board for the Cuban American National Council and a board member for the Smithsonian Latino Center.